Analysis of the Two-Step Heterogeneous Transfer Learning for Laryngeal Blood Vessel Classification: Issue and Improvement

Accurate classification of laryngeal vascular as benign or malignant is crucial for early detection of laryngeal cancer. However, organizations with limited access to laryngeal vascular images face challenges due to the lack of large and homogeneous public datasets for effective learning. Distinguished from the most familiar works, which directly transfer the ImageNet pre-trained models to the target domain for fine-tuning, this work pioneers exploring two-step heterogeneous transfer learning (THTL) for laryngeal lesion classification with nine deep-learning models, utilizing the diabetic retinopathy color fundus images, semantically non-identical yet vascular images, as the intermediate domain. Attention visualization technique, Layer Class Activate Map (LayerCAM), reveals a novel finding that yet the intermediate and the target domain both reflect vascular structure to a certain extent, the prevalent radial vascular pattern in the intermediate domain prevents learning the features of twisted and tangled vessels that distinguish the malignant class in the target domain, summarizes a vital rule for laryngeal lesion classification using THTL. To address this, we introduce an enhanced fine-tuning strategy in THTL called Step-Wise Fine-Tuning (SWFT) and apply it to the ResNet models. SWFT progressively refines model performance by accumulating fine-tuning layers from back to front, guided by the visualization results of LayerCAM. Comparison with the original THTL approach shows significant improvements. For ResNet18, the accuracy and malignant recall increases by 26.1% and 79.8%, respectively, while for ResNet50, these indicators improve by 20.4% and 62.2%, respectively.