Papers
Topics
Authors
Recent
Gemini 2.5 Flash
Gemini 2.5 Flash
139 tokens/sec
GPT-4o
47 tokens/sec
Gemini 2.5 Pro Pro
43 tokens/sec
o3 Pro
4 tokens/sec
GPT-4.1 Pro
47 tokens/sec
DeepSeek R1 via Azure Pro
28 tokens/sec
2000 character limit reached

Towards Risk Analysis of the Impact of AI on the Deliberate Biological Threat Landscape (2401.12755v3)

Published 23 Jan 2024 in cs.CY

Abstract: The perception that the convergence of biological engineering and AI could enable increased biorisk has recently drawn attention to the governance of biotechnology and artificial intelligence. The 2023 Executive Order, Executive Order on the Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence, requires an assessment of how artificial intelligence can increase biorisk. Within this perspective, quantitative and qualitative frameworks for evaluating biorisk are presented. Both frameworks are exercised using notional scenarios and their benefits and limitations are then discussed. Finally, the perspective concludes by noting that assessment and evaluation methodologies must keep pace with advances of AI in the life sciences.

Definition Search Book Streamline Icon: https://streamlinehq.com
References (16)
  1. “Society for risk analysis glossary”, 2018 URL: https://www.sra.org/wp-content/uploads/2020/04/SRA-Glossary-FINAL.pdf
  2. Paul Berg “Asilomar 1975: DNA modification secured” Number: 7211 Publisher: Nature Publishing Group In Nature 455.7211, 2008, pp. 290–291 DOI: 10.1038/455290a
  3. “Biodefense in the Age of Synthetic Biology” Washington, D.C.: National Academies Press, 2018 DOI: 10.17226/24890
  4. Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology, National Research Council “Biotechnology Research in an Age of Terrorism” Washington, D.C.: National Academies Press, 2004 DOI: 10.17226/10827
  5. “Virology under the Microscope—a Call for Rational Discourse” Publisher: American Society for Microbiology In Journal of Virology 97.2, 2023, pp. e00089–23 DOI: 10.1128/jvi.00089-23
  6. Helena Foundation “Biosecurity in the Age of AI: Chairperson’s Statement”, 2023 URL: https://www.helenabiosecurity.org/
  7. Jonathan B. Tucker “Innovation, Dual Use, and Security” Cambridge, Massachusetts: The MIT Press, 2012
  8. Ahmad S Khalil and James J Collins “Synthetic biology: applications come of age” Publisher: Nature Publishing Group UK London In Nature Reviews Genetics 11.5, 2010, pp. 367–379
  9. “PaperQA: Retrieval-Augmented Generative Agent for Scientific Research” arXiv:2312.07559 [cs] arXiv, 2023 DOI: 10.48550/arXiv.2312.07559
  10. “Machine learning optimization of candidate antibody yields highly diverse sub-nanomolar affinity antibody libraries” Number: 1 Publisher: Nature Publishing Group In Nature Communications 14.1, 2023, pp. 3454 DOI: 10.1038/s41467-023-39022-2
  11. Christopher A. Mouton, Caleb Lucas and Ella Guest “The Operational Risks of AI in Large-Scale Biological Attacks: A Red-Team Approach”, 2023 URL: https://www.rand.org/pubs/research_reports/RRA2977-1.html
  12. “Who Should We Fear More: Biohackers, Disgruntled Postdocs, or Bad Governments? A Simple Risk Chain Model of Biorisk” In Health Security 18.3, 2020, pp. 155–163 DOI: 10.1089/hs.2019.0115
  13. Jonas B. Sandbrink “Artificial intelligence and biological misuse: Differentiating risks of language models and biological design tools” arXiv:2306.13952 [cs] arXiv, 2023 DOI: 10.48550/arXiv.2306.13952
  14. “The Convergence of Artificial Intelligence and the Life Sciences”, 2023 URL: https://www.nti.org/analysis/articles/the-convergence-of-artificial-intelligence-and-the-life-sciences/
  15. U.S. Department of State “Adherence to and Compliance With Arms Contorl, Nonproliferation, And Disarmament Agreements and Commitments”, 2023, pp. 22–28 URL: https://www.state.gov/wp-content/uploads/2023/04/13APR23-FINAL-2023-Treaty-Compliance-Report-UNCLASSIFIED-UNSOURCED.pdf
  16. The White House “Executive Order on the Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence” In The White House, 2023 URL: https://www.whitehouse.gov/briefing-room/presidential-actions/2023/10/30/executive-order-on-the-safe-secure-and-trustworthy-development-and-use-of-artificial-intelligence/

Summary

We haven't generated a summary for this paper yet.