Integrating LLM, EEG, and Eye-Tracking Biomarker Analysis for Word-Level Neural State Classification in Semantic Inference Reading Comprehension

With the recent proliferation of LLMs, such as Generative Pre-trained Transformers (GPT), there has been a significant shift in exploring human and machine comprehension of semantic language meaning. This shift calls for interdisciplinary research that bridges cognitive science and NLP. This pilot study aims to provide insights into individuals' neural states during a semantic relation reading-comprehension task. We propose jointly analyzing LLMs, eye-gaze, and electroencephalographic (EEG) data to study how the brain processes words with varying degrees of relevance to a keyword during reading. We also use a feature engineering approach to improve the fixation-related EEG data classification while participants read words with high versus low relevance to the keyword. The best validation accuracy in this word-level classification is over 60\% across 12 subjects. Words of high relevance to the inference keyword had significantly more eye fixations per word: 1.0584 compared to 0.6576 when excluding no-fixation words, and 1.5126 compared to 1.4026 when including them. This study represents the first attempt to classify brain states at a word level using LLM knowledge. It provides valuable insights into human cognitive abilities and the realm of AGI, and offers guidance for developing potential reading-assisted technologies.