Understanding the Effect of Counterfactual Explanations on Trust and Reliance on AI for Human-AI Collaborative Clinical Decision Making

AI is increasingly being considered to assist human decision-making in high-stake domains (e.g. health). However, researchers have discussed an issue that humans can over-rely on wrong suggestions of the AI model instead of achieving human AI complementary performance. In this work, we utilized salient feature explanations along with what-if, counterfactual explanations to make humans review AI suggestions more analytically to reduce overreliance on AI and explored the effect of these explanations on trust and reliance on AI during clinical decision-making. We conducted an experiment with seven therapists and ten laypersons on the task of assessing post-stroke survivors' quality of motion, and analyzed their performance, agreement level on the task, and reliance on AI without and with two types of AI explanations. Our results showed that the AI model with both salient features and counterfactual explanations assisted therapists and laypersons to improve their performance and agreement level on the task when right' AI outputs are presented. While both therapists and laypersons over-relied onwrong' AI outputs, counterfactual explanations assisted both therapists and laypersons to reduce their over-reliance on wrong' AI outputs by 21\% compared to salient feature explanations. Specifically, laypersons had higher performance degrades by 18.0 f1-score with salient feature explanations and 14.0 f1-score with counterfactual explanations than therapists with performance degrades of 8.6 and 2.8 f1-scores respectively. Our work discusses the potential of counterfactual explanations to better estimate the accuracy of an AI model and reduce over-reliance onwrong' AI outputs and implications for improving human-AI collaborative decision-making.