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Designing a Magnetic Micro-Robot for Transporting Filamentous Microcargo (2307.00713v1)

Published 3 Jul 2023 in cs.RO

Abstract: In recent years, the medical industry has witnessed a growing interest in minimally invasive procedures, with magnetic microrobots emerging as a promising approach. These micro-robots possess the ability to navigate through various media, including viscoelastic and non-Newtonian fluids, enabling targeted drug delivery and medical interventions. Many current designs, inspired by micro-swimmers in biological systems like bacteria and sperm, employ a contact-based method for transporting a payload. Adhesion between the cargo and the carrier can make release at the target site problematic. In this project, our primary objective was to explore the potential of a helical micro-robot for non-contact drug or cargo delivery. We conducted a comprehensive study on the shape and geometrical parameters of the helical microrobot, specifically focusing on its capability to transport passive filaments. Based on our analysis, we propose a novel design consisting of three sections with alternating handedness, including two pulling and one pushing microhelices, to enhance the capture and transport of passive filaments in Newtonian fluids using a non-contact approach. We then simulated the process of capturing and transporting the passive filament, and tested the functionality of the newly designed micro-robot. Our findings offer valuable insights into the physics of helical micro-robots and their potential for medical procedures and drug delivery. Furthermore, the proposed non-contact method for delivering filamentous cargo could lead to the development of more efficient and effective microrobots for medical applications.

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References (40)
  1. A magnetically guided self-rolled microrobot for targeted drug delivery, real-time x-ray imaging, and microrobot retrieval. Advanced Healthcare Materials, 10(6):2001681, 2021.
  2. Microrobots for minimally invasive medicine. Annual review of biomedical engineering, 12:55–85, 2010.
  3. Bio-inspired magnetic swimming microrobots for biomedical applications. Nanoscale, 5(4):1259–1272, 2013.
  4. Targeted drug delivery and imaging using mobile milli/microrobots: A promising future towards theranostic pharmaceutical design. Current pharmaceutical design, 22(11):1418–1428, 2016.
  5. Medical microrobot—a drug delivery capsule endoscope with active locomotion and drug release mechanism: Proof of concept. International Journal of Control, Automation and Systems, 18:65–75, 2020.
  6. Sperm micromotors for cargo delivery through flowing blood. ACS nano, 14(3):2982–2993, 2020.
  7. Sperm-hybrid micromotor for targeted drug delivery. ACS nano, 12(1):327–337, 2018.
  8. A capsule-type microrobot with pick-and-drop motion for targeted drug and cell delivery. Advanced healthcare materials, 7(9):1700985, 2018.
  9. Stephen Ornes. Medical microrobots have potential in surgery, therapy, imaging, and diagnostics. Proceedings of the National Academy of Sciences, 114(47):12356–12358, 2017.
  10. Mobility experiments with microrobots for minimally invasive intraocular surgery. Investigative ophthalmology & visual science, 54(4):2853–2863, 2013.
  11. Antonello Forgione. In vivo microrobots for natural orifice transluminal surgery. current status and future perspectives. Surgical oncology, 18(2):121–129, 2009.
  12. Mobile microrobots for bioengineering applications. Lab on a Chip, 17(10):1705–1724, 2017.
  13. Engineering microrobots for targeted cancer therapies from a medical perspective. Nature Communications, 11(1):5618, 2020.
  14. Microrobots derived from variety plant pollen grains for efficient environmental clean up and as an anti-cancer drug carrier. Advanced Functional Materials, 30(19):2000112, 2020.
  15. Magnetocatalytic graphene quantum dots janus micromotors for bacterial endotoxin detection. Angewandte Chemie International Edition, 56(24):6957–6961, 2017.
  16. A thermo-electromagnetically actuated microrobot for the targeted transport of therapeutic agents. International Journal of Control, Automation and Systems, 16:1341–1354, 2018.
  17. Magnetic microswarm composed of porous nanocatalysts for targeted elimination of biofilm occlusion. ACS nano, 15(3):5056–5067, 2021.
  18. Photoacoustic imaging-trackable magnetic microswimmers for pathogenic bacterial infection treatment. ACS nano, 14(3):2880–2893, 2020.
  19. Fuel-free light-driven micro/nanomachines: artificial active matter mimicking nature. Chemical Society Reviews, 48(19):4966–4978, 2019.
  20. A diatom-based biohybrid microrobot with a high drug-loading capacity and ph-sensitive drug release for target therapy. Acta Biomaterialia, 154:443–453, 2022.
  21. Bioinspired helical microswimmers based on vascular plants. Nano letters, 14(1):305–310, 2014.
  22. A helical microrobot with an optimized propeller-shape for propulsion in viscoelastic biological media. Robotics, 8(4):87, 2019.
  23. Magnetically actuated drug delivery helical microrobot with magnetic nanoparticle retrieval ability. ACS applied materials & interfaces, 13(17):19633–19647, 2021.
  24. Cellular cargo delivery: Toward assisted fertilization by sperm-carrying micromotors. Nano letters, 16(1):555–561, 2016.
  25. Light-triggered drug release from 3d-printed magnetic chitosan microswimmers. ACS nano, 12(9):9617–9625, 2018.
  26. Adaptive controller and observer for a magnetic microrobot. IEEE Transactions on Robotics, 29(4):1060–1067, 2013.
  27. Magnetic navigation system for the precise helical and translational motions of a microrobot in human blood vessels. Journal of Applied Physics, 111(7):07E702, 2012.
  28. Magnetic torque–driven living microrobots for increased tumor infiltration. Science Robotics, 7(71):eabo0665, 2022.
  29. Independent position control of two identical magnetic microrobots in a plane using rotating permanent magnets. Journal of Micro-Bio Robotics, 17:59–67, 2021.
  30. Flagella-like propulsion for microrobots using a nanocoil and a rotating electromagnetic field. In Proceedings 2007 IEEE international conference on robotics and automation, pages 1128–1133. IEEE, 2007.
  31. Edward M Purcell. The efficiency of propulsion by a rotating flagellum. Proceedings of the National Academy of Sciences, 94(21):11307–11311, 1997.
  32. AT Chwang and Th Y Wu. A note on the helical movement of micro-organisms. Proceedings of the Royal Society of London. Series B. Biological Sciences, 178(1052):327–346, 1971.
  33. Generating mobile fluidic traps for selective three-dimensional transport of microobjects. Applied Physics Letters, 105(11):114102, 2014.
  34. Magnetic helical micro-and nanorobots: Toward their biomedical applications. Engineering, 1(1):021–026, 2015.
  35. The method of regularized stokeslets in three dimensions: analysis, validation, and application to helical swimming. Physics of Fluids, 17(3):031504, 2005.
  36. Ricardo Cortez. The method of regularized stokeslets. SIAM Journal on Scientific Computing, 23(4):1204–1225, 2001.
  37. Impacts of multiflagellarity on stability and speed of bacterial locomotion. Physical Review E, 98(4):042419, 2018.
  38. How should microrobots swim? The international journal of Robotics Research, 28(11-12):1434–1447, 2009.
  39. James Gray and GJ Hancock. The propulsion of sea-urchin spermatozoa. Journal of Experimental Biology, 32(4):802–814, 1955.
  40. Propulsion of microorganisms by a helical flagellum. Proceedings of the National Academy of Sciences, 110(5):E338–E347, 2013.
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Authors (2)
  1. Sepehr Ghadami (1 paper)
  2. Henry Shum (9 papers)

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