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DiGress: Discrete Denoising diffusion for graph generation (2209.14734v4)

Published 29 Sep 2022 in cs.LG

Abstract: This work introduces DiGress, a discrete denoising diffusion model for generating graphs with categorical node and edge attributes. Our model utilizes a discrete diffusion process that progressively edits graphs with noise, through the process of adding or removing edges and changing the categories. A graph transformer network is trained to revert this process, simplifying the problem of distribution learning over graphs into a sequence of node and edge classification tasks. We further improve sample quality by introducing a Markovian noise model that preserves the marginal distribution of node and edge types during diffusion, and by incorporating auxiliary graph-theoretic features. A procedure for conditioning the generation on graph-level features is also proposed. DiGress achieves state-of-the-art performance on molecular and non-molecular datasets, with up to 3x validity improvement on a planar graph dataset. It is also the first model to scale to the large GuacaMol dataset containing 1.3M drug-like molecules without the use of molecule-specific representations.

Citations (278)

Summary

  • The paper introduces a novel discrete denoising diffusion process that sequentially refines categorical node and edge attributes for graph generation.
  • It leverages a graph transformer network with algorithmic enhancements to preserve marginal distributions and improve sample validity on diverse datasets.
  • The model conditions graph generation on specific properties, demonstrating scalability and potential for applications such as molecular design.

An Overview of DiGress: Discrete Denoising Diffusion for Graph Generation

The paper "DiGress: Discrete Denoising Diffusion for Graph Generation" introduces a novel approach to the domain of generative models, specifically targeting the generation of graphs with categorical node and edge attributes. The proposed model, termed DiGress, leverages a discrete denoising diffusion process to incrementally refine graph representations by introducing and then removing noise in the form of edge additions or deletions and changes to node or edge categories.

DiGress stands apart from prior methods, which primarily embedded graphs into continuous spaces, by employing a discrete diffusion mechanism that preserves the intrinsic sparsity and unordered nature of graphs, thereby maintaining structural information like connectivity, which continuous models often obscure. The diffusion process in DiGress is underpinned by a Markov chain designed to ensure the marginal distribution of node and edge types remains consistent, which is a critical factor in improving the quality of generated samples.

A key innovation of DiGress is the transformation of the problem of learning distributions over graphs into sequential node and edge classification tasks, managed by a graph transformer network. This model also introduces algorithmic enhancements such as a novel noise model that retains marginal distributions and the integration of auxiliary graph-theoretic features, which help mitigate the representational limitations typical of graph neural networks. In addition, DiGress offers a procedure for conditioning graph generation on overarching graph-level features, an aspect critical for practical applications like designing molecules that meet specific criteria.

Empirically, DiGress demonstrates state-of-the-art performance across several datasets, notably achieving a threefold increase in validity improvement on planar graph datasets. It also scales effectively to large datasets like GuacaMol, containing over 1.3 million drug-like molecules, without relying on molecule-specific representations—a significant advancement in the field.

The model's architecture includes permutation equivariant features, ensuring robustness against node permutation issues prevalent in graph data, and facilitates efficient sampling through a carefully structured posterior estimation process. Moreover, the model's incorporation of spectral and structural features, which are resistant to the limitations of traditional message-passing networks, underscores its capacity to handle a diverse range of graph generation tasks.

In terms of implications, DiGress presents a substantial development in the field of generative models for graph data, offering practicality for tasks ranging from molecular design to traffic modeling. Its ability to conditionally generate graphs based on specific properties could herald further advancements in personalized and targeted molecule synthesis. The model's scalability and robust handling of complex datasets suggest significant potential for DiGress in AI-driven scientific research and real-world applications.

Prospective future directions could involve refining the model's ability to handle even larger and more complex datasets, exploring additional auxiliary features to complement the diffusion process, and investigating the integration of DiGress with domain-specific knowledge bases to enhance its applicability in specialized fields like cheminformatics and bioinformatics. The discrete nature of the model also opens pathways to explore its utility in domains beyond graph data, where similar challenges of sparsity and unordered structures are present.

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