Reconstructing Strings from Substrings: Optimal Randomized and Average-Case Algorithms (1808.00674v1)

Abstract: The problem called "String reconstruction from substrings" is a mathematical model of sequencing by hybridization that plays an important role in DNA sequencing. In this problem, we are given a blackbox oracle holding an unknown string ${\mathcal X}$ and are required to obtain (reconstruct) ${\mathcal X}$ through "substring queries" $Q(S)$. $Q(S)$ is given to the oracle with a string $S$ and the answer of the oracle is Yes if ${\mathcal X}$ includes $S$ as a substring and No otherwise. Our goal is to minimize the number of queries for the reconstruction. In this paper, we deal with only binary strings for ${\mathcal X}$ whose length $n$ is given in advance by using a sequence of good $S$'s. In 1995, Skiena and Sundaram first studied this problem and obtained an algorithm whose query complexity is $n+O(\log n)$. Its information theoretic lower bound is $n$, and they posed an obvious open question; if we can remove the $O(\log n)$ additive term. No progress has been made until now. This paper gives two partially positive answers to this open question. One is a randomized algorithm whose query complexity is $n+O(1)$ with high probability and the other is an average-case algorithm also having a query complexity of $n+O(1)$ on average. The $n$ lower bound is still true for both cases, and hence they are optimal up to an additive constant.