Emergent Mind
Equivalence Classes of Optimal Structures in HP Protein Models Including Side Chains
(0910.3848)
Published Oct 20, 2009
in
cs.CE
and
q-bio.BM
Abstract
Lattice protein models, as the Hydrophobic-Polar (HP) model, are a common abstraction to enable exhaustive studies on structure, function, or evolution of proteins. A main issue is the high number of optimal structures, resulting from the hydrophobicity-based energy function applied. We introduce an equivalence relation on protein structures that correlates to the energy function. We discuss the efficient enumeration of optimal representatives of the corresponding equivalence classes and the application of the results.
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